XBI holdingswhat does SPDR S&P Biotech ETF hold?
Largest positions from the fund’s most recent SEC Form N-PORT filing (reported quarterly, filed with a lag). Percentages are of net assets. SEC Form N-PORT · as of 2026-03-31
Top 150 positions shownTop-10 holdings weight: 20.4%as of 2026-03-31
| # | Holding | Weight | Value |
|---|---|---|---|
| 1 | State Street Global AdvisorsGVMXX | 8.01% | $595.46M |
| 2 | Apellis Pharmaceuticals Inc | 1.83% | $136.40M |
| 3 | Alkermes PLC | 1.45% | $107.88M |
| 4 | Madrigal Pharmaceuticals IncMDGL | 1.38% | $102.81M |
| 5 | TG Therapeutics IncTGTX | 1.35% | $100.33M |
| 6 | Insmed IncINSM | 1.34% | $99.39M |
| 7 | Scholar Rock Holding CorpSRRK | 1.30% | $96.45M |
| 8 | Apogee Therapeutics IncAPGE | 1.28% | $95.48M |
| 9 | Protagonist Therapeutics IncPTGX | 1.24% | $92.55M |
| 10 | Summit Therapeutics IncSMMT | 1.24% | $92.27M |
| 11 | United Therapeutics CorpUTHR | 1.24% | $92.23M |
| 12 | Praxis Precision Medicines IncPRAX | 1.24% | $91.91M |
| 13 | Arrowhead Pharmaceuticals IncARWR | 1.23% | $91.43M |
| 14 | Cogent Biosciences IncCOGT | 1.22% | $90.38M |
| 15 | Bridgebio Pharma IncBBIO | 1.19% | $88.13M |
| 16 | PTC Therapeutics IncPTCT | 1.18% | $87.89M |
| 17 | Cytokinetics IncCYTK | 1.18% | $87.76M |
| 18 | Alnylam Pharmaceuticals IncALNY | 1.18% | $87.48M |
| 19 | Exelixis IncEXEL | 1.17% | $87.03M |
| 20 | Nuvalent Inc | 1.17% | $86.75M |
| 21 | Kymera Therapeutics IncKYMR | 1.16% | $86.56M |
| 22 | CG oncology IncCGON | 1.16% | $86.42M |
| 23 | Natera IncNTRA | 1.16% | $86.18M |
| 24 | Neurocrine Biosciences IncNBIX | 1.16% | $86.16M |
| 25 | Twist Bioscience CorpTWST | 1.16% | $85.92M |
| 26 | Krystal Biotech IncKRYS | 1.15% | $85.83M |
| 27 | Vaxcyte IncPCVX | 1.15% | $85.58M |
| 28 | Mirum Pharmaceuticals IncMIRM | 1.15% | $85.31M |
| 29 | Amicus Therapeutics Inc | 1.15% | $85.25M |
| 30 | Ionis Pharmaceuticals IncIONS | 1.14% | $85.07M |
| 31 | Travere Therapeutics IncTVTX | 1.14% | $85.07M |
| 32 | Arcellx Inc | 1.14% | $85.06M |
| 33 | Regeneron Pharmaceuticals IncREGN | 1.14% | $84.53M |
| 34 | Incyte CorpINCY | 1.13% | $84.24M |
| 35 | Celcuity IncCELC | 1.12% | $83.54M |
| 36 | Revolution Medicines IncRVMD | 1.11% | $82.74M |
| 37 | Halozyme Therapeutics IncHALO | 1.11% | $82.37M |
| 38 | Rhythm Pharmaceuticals IncRYTM | 1.10% | $81.85M |
| 39 | Biogen IncBIIB | 1.10% | $81.56M |
| 40 | Arcutis Biotherapeutics IncARQT | 1.09% | $80.99M |
| 41 | AbbVie IncABBV | 1.09% | $80.93M |
| 42 | Gilead Sciences IncGILD | 1.09% | $80.87M |
| 43 | CRISPR Therapeutics AG | 1.09% | $80.72M |
| 44 | BioMarin Pharmaceutical IncBMRN | 1.07% | $79.35M |
| 45 | Roivant Sciences Ltd | 1.07% | $79.34M |
| 46 | Amgen IncAMGN | 1.06% | $79.01M |
| 47 | ImmunityBio IncIBRX | 1.06% | $78.57M |
| 48 | Beam Therapeutics IncBEAM | 1.04% | $77.41M |
| 49 | Viking Therapeutics IncVKTX | 1.04% | $77.09M |
| 50 | Vera Therapeutics IncVERA | 1.03% | $76.92M |
| 51 | Moderna IncMRNA | 1.03% | $76.90M |
| 52 | Vertex Pharmaceuticals IncVRTX | 1.03% | $76.84M |
| 53 | Erasca IncERAS | 1.03% | $76.58M |
| 54 | ACADIA Pharmaceuticals IncACAD | 1.02% | $75.97M |
| 55 | Sarepta Therapeutics IncSRPT | 0.89% | $66.52M |
| 56 | Agios Pharmaceuticals IncAGIO | 0.88% | $65.30M |
| 57 | Ultragenyx Pharmaceutical IncRARE | 0.88% | $65.11M |
| 58 | Disc Medicine IncIRON | 0.87% | $64.71M |
| 59 | Immunome IncIMNM | 0.86% | $64.18M |
| 60 | Immunovant IncIMVT | 0.86% | $63.75M |
| 61 | BioCryst Pharmaceuticals Inc | 0.85% | $63.36M |
| 62 | Veracyte Inc | 0.85% | $63.06M |
| 63 | Dyne Therapeutics Inc | 0.84% | $62.32M |
| 64 | Catalyst Pharmaceuticals Inc | 0.76% | $56.16M |
| 65 | Syndax Pharmaceuticals Inc | 0.74% | $54.74M |
| 66 | Denali Therapeutics Inc | 0.73% | $54.35M |
| 67 | Ideaya Biosciences Inc | 0.73% | $54.27M |
| 68 | Spyre Therapeutics Inc | 0.73% | $53.95M |
| 69 | GRAIL Inc | 0.72% | $53.81M |
| 70 | Viridian Therapeutics Inc | 0.70% | $52.17M |
| 71 | Recursion Pharmaceuticals Inc | 0.69% | $51.37M |
| 72 | Kodiak Sciences Inc | 0.69% | $51.24M |
| 73 | Soleno Therapeutics Inc | 0.67% | $50.09M |
| 74 | Dianthus Therapeutics Inc | 0.66% | $49.23M |
| 75 | Intellia Therapeutics Inc | 0.65% | $48.12M |
| 76 | Mineralys Therapeutics Inc | 0.65% | $48.04M |
| 77 | Arcus Biosciences Inc | 0.63% | $46.73M |
| 78 | Ardelyx Inc | 0.62% | $45.91M |
| 79 | ADMA Biologics Inc | 0.60% | $44.29M |
| 80 | Nurix Therapeutics Inc | 0.59% | $43.55M |
| 81 | Tango Therapeutics Inc | 0.56% | $41.27M |
| 82 | Celldex Therapeutics Inc | 0.52% | $38.78M |
| 83 | Novavax Inc | 0.51% | $38.00M |
| 84 | Oruka Therapeutics Inc | 0.50% | $37.33M |
| 85 | Olema Pharmaceuticals Inc | 0.50% | $36.86M |
| 86 | Stoke Therapeutics Inc | 0.49% | $36.65M |
| 87 | Vericel Corp | 0.48% | $35.91M |
| 88 | Capricor Therapeutics Inc | 0.48% | $35.63M |
| 89 | Palvella Therapeutics Inc | 0.46% | $34.18M |
| 90 | Biohaven Ltd | 0.44% | $32.53M |
| 91 | Monte Rosa Therapeutics Inc | 0.44% | $32.35M |
| 92 | Corvus Pharmaceuticals Inc | 0.42% | $30.97M |
| 93 | Iovance Biotherapeutics Inc | 0.38% | $28.57M |
| 94 | AnaptysBio Inc | 0.38% | $28.41M |
| 95 | Relay Therapeutics Inc | 0.38% | $28.17M |
| 96 | uniQure NV | 0.37% | $27.75M |
| 97 | ORIC Pharmaceuticals Inc | 0.37% | $27.51M |
| 98 | MannKind Corp | 0.36% | $26.79M |
| 99 | CareDx Inc | 0.35% | $25.70M |
| 100 | Taysha Gene Therapies Inc | 0.34% | $25.21M |
| 101 | Tyra Biosciences Inc | 0.34% | $25.10M |
| 102 | Geron Corp | 0.33% | $24.75M |
| 103 | Day One Biopharmaceuticals Inc | 0.32% | $23.87M |
| 104 | Precigen Inc | 0.31% | $23.24M |
| 105 | Vir Biotechnology Inc | 0.30% | $22.65M |
| 106 | KalVista Pharmaceuticals Inc | 0.29% | $21.70M |
| 107 | CytomX Therapeutics Inc | 0.29% | $21.20M |
| 108 | Annexon Inc | 0.28% | $21.18M |
| 109 | Kura Oncology Inc | 0.28% | $20.51M |
| 110 | Inhibrx Biosciences Inc | 0.27% | $19.94M |
| 111 | SELLAS Life Sciences Group Inc | 0.27% | $19.84M |
| 112 | Janux Therapeutics Inc | 0.27% | $19.80M |
| 113 | Compass Therapeutics Inc | 0.26% | $19.49M |
| 114 | Savara Inc | 0.26% | $19.41M |
| 115 | Rigel Pharmaceuticals Inc | 0.26% | $19.17M |
| 116 | Sana Biotechnology Inc | 0.26% | $19.15M |
| 117 | Cullinan Therapeutics Inc | 0.25% | $18.58M |
| 118 | ARS Pharmaceuticals Inc | 0.24% | $17.77M |
| 119 | Zenas Biopharma Inc | 0.24% | $17.72M |
| 120 | Xencor Inc | 0.23% | $17.15M |
| 121 | Replimune Group Inc | 0.23% | $16.82M |
| 122 | Sionna Therapeutics Inc | 0.22% | $16.70M |
| 123 | Vor BioPharma Inc | 0.22% | $16.63M |
| 124 | ArriVent Biopharma Inc | 0.22% | $16.17M |
| 125 | Ironwood Pharmaceuticals Inc | 0.19% | $14.04M |
| 126 | Bicara Therapeutics Inc | 0.19% | $13.96M |
| 127 | Prime Medicine Inc | 0.19% | $13.85M |
| 128 | Altimmune Inc | 0.18% | $13.41M |
| 129 | Absci Corp | 0.18% | $13.35M |
| 130 | Emergent BioSolutions Inc | 0.18% | $13.06M |
| 131 | Allogene Therapeutics Inc | 0.17% | $12.72M |
| 132 | Hyperliquid Strategies Inc | 0.17% | $12.48M |
| 133 | 4D Molecular Therapeutics Inc | 0.17% | $12.27M |
| 134 | Vanda Pharmaceuticals Inc | 0.16% | $11.77M |
| 135 | REGENXBIO Inc | 0.15% | $11.43M |
| 136 | Lexeo Therapeutics Inc | 0.14% | $10.69M |
| 137 | Verastem Inc | 0.14% | $10.68M |
| 138 | Arbutus Biopharma Corp | 0.14% | $10.21M |
| 139 | Myriad Genetics Inc | 0.13% | $9.72M |
| 140 | Prothena Corp PLC | 0.13% | $9.56M |
| 141 | Ocugen Inc | 0.13% | $9.45M |
| 142 | Rocket Pharmaceuticals Inc | 0.13% | $9.33M |
| 143 | MiMedx Group Inc | 0.12% | $9.02M |
| 144 | Akebia Therapeutics Inc | 0.11% | $8.39M |
| 145 | Anavex Life Sciences Corp | 0.11% | $8.15M |
| 146 | CONTRA METSERA INC | 0.10% | $7.50M |
| 147 | Invivyd Inc | 0.10% | $7.35M |
| 148 | Perspective Therapeutics Inc | 0.10% | $7.15M |
| 149 | State Street Global Advisors | 0.06% | $4.70M |
| 150 | Damora Therapeutics Inc | 0.03% | $2.43M |
ETF holdings
SEC Form N-PORT data · Reported quarterly, filed with a lag · For reference only · Not investment advice